Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets
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منابع مشابه
Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets
We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, res...
متن کاملRegeneration of pancreatic beta cells.
Diabetes mellitus results from inadequate mass of insulin-producing pancreatic beta cells. Type 1 diabetes is characterized by absolute loss of beta cells due to autoimmune-mediated destruction. Type 2 diabetes is characterized by relative deficiency of beta cells due to lack of compensation for insulin resistance. Restoration of deficient beta cell mass by transplantation from exogenous source...
متن کاملHISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF PANCREATIC ISLET BETA CELLS OF DIABETIC RATS TREATED WITH ORAL VANADYL SULPHATE
Vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. The aim of the present study was to clarify histological and immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl sulphate (VS)-treated streptozotocin (STZ) induced diabetic rats. Male Wi star rats were made diabetic by injecting a single intravenous dose of STZ (...
متن کاملPancreatic beta-cells: from generation to regeneration.
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprisi...
متن کاملimmunohistochemical study of the pancreatic islet beta cells of diabetic rats treated with oral vanadyl sulphate
introduction: vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify immunohistochemical changes that occur in the pancreatic beta ([pancreatic islet beta]) cells of vanadyl sulphate (vs) treated stz induced diabetic rats. materials and methods: male wistar rats were made diabetic with injecting a single intr...
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ژورنال
عنوان ژورنال: Journal of Diabetes Research
سال: 2014
ISSN: 2314-6745,2314-6753
DOI: 10.1155/2014/540242